This is a pretty big advantage.
I use Private Relay as a sort of VPN split-tunnel. What I consider privacy sensitive is my browsing activity and messaging/calls. Signal/iMessage/FaceTime encrypt the messaging information with Private Relay (which works with NextDNS) protecting browsing data.
But then I can leave my app connections I do not consider sensitive alone and avoid steaming, banking, or Tesla app problems often encountered with a VPN on.