I recently had to do a factory reset on a Pixel device running GrapheneOS, and lost access to a couple apps like CashApp and Snapchat. Thankfully, Snapchat could be rolled back to to an old version and I could log in and update the app, but other apps like CashApp are using more advanced detection like PLay Integrity to block people out of their accounts. I would say for me it was only a couple of apps, but more devs might be adopting the tech. For me, I can live without some of these services, but for more average users you would have to do a lot more research into the apps you use to see if you are affected.