Any idea how to block domain's globally on android?

I am not sure what you meant by it ? . Do you mean we can use the firewall feature as well as connect to a Wireguard VPN server through the invizible prp app. I tried to checkout the app but i couldn’t find a way to setup this. (firewall + vpn) . Would be interested in knowing if there was a way.
(note - i am already aware of the use of work profile to run two vpn slots and use firewall in one and vpn in another but its inconvenient to use can leads to leakages.)